 DR.S.ARAVAMUDHAN http://www.ugc-inno-nehu.com/ |
 BIODATA CONTACT INFO Curriculum Vitae/Resume webpages_list http://nehuacin.tripod.com Phone Mobile: +919862053872 EMAIL:- inboxnehu_sa@yahoo.com saravamudhan@hotmail.com aram1121944@gmail.com |
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S.Aravamudhan Department of Chemistry North Eastern Hill University Shillong 793022 Meghalaya saravamudhan@.nehu.ac.in
Abstract Book: P-01 at page 12 While establishing the trends to facilitate retrieval of information relevant for the Biology, first a beginning is made to know the prevailing laws in Nature as much is possible by the studies in physical sciences. This essentially consists of observing and experimenting the inanimate objects around and deduces the laws to find how the living beings are made up of such processes constituting characteristically �life�. The computers have revolutionized the ways to obtain solutions to complex and time consuming problems and adding control systems which translate the computational results into realizable work to monitor and regulate instruments and machines replacing the necessity for human surveillance at the installations. In fact all these regulatory feed back techniques devised in control systems require an understanding of how living systems perform actions with the capability to perceive using the sense organs. Thus for such a parallelism to be effective it becomes required to document enormous amount of information and once again, the computer aided informatics becomes the resource generating method. The importance of information technology finds naturally its importance. The tools used for the study in biological sciences comprises of inevitably the spectroscopic techniques developed by the requirements physical science with the contribution from the electronics and computer sciences making the rapid progress possible. Nuclear Magnetic Resonance Technique is one of the spectroscopic technique and the results from NMR studies of biological systems indicate the inevitability of this technique among all the other techniques for Bioinformatics. An exposure to the variety of problems in Biological Systems to which the NMR technique has been elegantly applied seem to bring about a revelation that without such results the investigators would have probably required much longer and tough efforts to know the importance of certain biological processes. This in turn makes possible to advance using other techniques on the understanding of the Biological processes. An exposure to such important results in NMR on Biological systems would be given in such a way that it becomes convincing to those who are totally aliens to the field of NMR. References to important publications would be listed while providing the review of the results from various NMR research groups contributing to Biological Research. MMV BHU Varanasi 23rd March 2006 Find below the poster materials Click on the sign SHEET-# and download the MSWORD Document |
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 CLICK on logo above to display the URL: http://www.bmrb.wisc.edu This info about BMRB was secured during the participation at ICMRBS2005 COPIED below is the text from the BMRB website BMRB's mission is to collect, archive, and disseminate (worldwide in the public domain) the important quantitative data derived from NMR spectroscopic investigations of biological macromolecules. Relevant data are deposited by the scientists who generate them, and in consultation with these scientists, BMRB resolves any problems with the self-consistency and completeness of the deposition. In collaboration with the Protein Data Bank, BMRB provides links between the spectral data and associated atomic coordinates. BMRB works with the user community to develop formats for these data that can be parsed by computers and used for knowledge generation, alone and in conjunction with information from other databases. BMRB's goal is to empower scientists in their analysis of the structure, dynamics, and chemistry of biological systems and to support further development of the field of biomolecular NMR spectroscopy. Through international collaborations and mirror sites, BMRB endeavors to involve the participation of a wider group of scientists and to enhance its services worldwide. |
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 Dr.S.Aravamudhan participated in the UGC sponsored workshop on "Computers in Chemistry" at Cotton College, Guwahati/ Certified as above. |
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From: "ComputationalBiology BHU" To: saravamudhan@nehu.ac.in Subject: Re: Preliminary registration NSWBCB06 at BHU Dear Dr Aravamudhan, I am pleased to know that you are in BHU.We are all at MMV,where we hope to see you tomorrow. You will be chairing a session at 11:30 am tomorrow. The little outdated Academic Program is at http://nswbcb.blogspot.com The talks and timings are same,only chairpersons have changed. Swati Dear Dr.Swati, I am already on the BHU Campus by now and I reply from a cybercafe just outside the BHU Campus entrance gate after I decided to walk out abit to find my way on the BHU campus. I shall talk to you about the POSTER tomorrow when we meet at the Venue of the SEMINAR. I read your message only now since I have been travelling since the
afternoon of 19th March 2006. S.Aravamudhan SO SORRY not to have replied earlier.For the past 4 days we have our server down and I have been at our Computer Lab all day and most of evening. Your accommodation in University Guest House has been booked from 21/3/06 to 24/3/06. You can catch an autorickshaw for BHU and ask directions at the main gate for University Guest house which is 5 mins away You can stroll down to MMV or call us at -2307603- we will have someone meet you after you are ready to come out.Meals are available at UGH Your poster session is at 1:00 pm om 23/3/06 The size of the board for Posters will be 120cm X 80 cms as is usual.
Looking forward to intercting with you. Swati |
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the participation in NSWBCB2006 at MMV, BHU during 22-24, March 2006, CLICK HERE |
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From: Prof. Veena Tandon To: saravamudhan@nehu.ac.in Sent: Monday, March 13, 2006 9:49 AM Subject: Re: Re: Re Registration NSWBCB06 at BHU Dear Prof. Aravamudhan, Good to know that you would be attending the seminar at BHU. The BIC
NEHU, not being involved in it in any way, has no comments to
make. V Tandon From: Sankarampadi ARAVAMUDHAN To: tandonveena@hotmail.com Sent: Sunday, March 12, 2006 12:05 PM Subject: Fwd: Re: Re Registration NSWBCB06 at BHU Dear Prof. Veena Tandon, I intend to particiapte in the National Seminar on Bioinformatics and Computaional Biology to be held at Mahila Mahavidyalaya Varnasi at BHU during March 22-23, 2006. In this connection I hereby forward these email correspondences with
the Organizers and the attachement for your kind perusal and i wish to
know if you would have any suggestions/comments particularly with respect
to the activities at the Centre for Bioinformatics, NEHU. S.Aravamudhan Date: Thu, 2 Mar 2006 20:14:20 -0800 (PST) From: Sankarampadi ARAVAMUDHAN Subject: Re: Re Registration NSWBCB06 at BHU To: ComputationalBiology BHU Dear Dr.Swati, Thanks for your reply. I can as well put up a poster since I have recently presented a paper at the Indian Biophysics Society annual meeting at Kolkata in the Biological spectroscopy Session. I have all those poster materials with me and I an include certain additional material so as to be bioinformatics and computational biology. http://geocities.com/sankarampadi/ForIbs2006.html For this I await your further requirements on submission of abstract
etc. I am sending this message from the venue of the ICMM2006 after whichi
shall return to shillong NEHU campus on 8th March 2006. I look forward to
know further from you when I am back in Shillong. CLICK HERE and
Jump to EVENT-III S.Aravmudhan Dear Dr Aravamudhan, Surprisingly both_ yr DD and cheque arrived together today. We have kept the DD and will return the cheque in your hand.We have you now on our Guesthouse list. However,I am sorry to repeat that we cannot have you give a lecture on NMR in our Seminar. However,if you are very keen to have a paper included we can include it in our poster presentation.We would prefer it if you could also report some work that you have done in the area of Structural Biology based on NMR. This is after I had put up your abstract for discussion in our Academic Committee again. I hope you understand.Thanks and do participate in our seminar. Dr Swati |
 pacificyew_050506 |
CLICK HERE to
display the source page from "SpectroscopyNow.com" for the material
below [May 5, 2006] Solid-state NMR studies of the molecular structure of Taxol Magnetic Resonance in Chemistry 2006, 44, 581-585 Yu Ho, Der-Lii M. Tzou and Feng-I Chu Abstract: Solid-state 13C{1H} cross-polarization/magic angle
spinning spectroscopy (CP/MAS) has been utilized to extract the molecular
structure information of Taxol, which is an anti-tumor therapeutic
medicine extracted from the yew bark. The 13C signals have chemical shift
values quite consistent with those measured in solution phase, and the
overall chemical shift range is over 200 ppm. Notably, most of the 13C
resonances of the taxane ring have two clearly resolved spectral
components except the resonance peaks of C-15, C-16 and C-17, which are
located at the central part of the taxane ring. On the basis of our NMR
data, we propose that these doublets originate from two slightly different
molecular conformations of the taxane ring and still the central part of
the ring remains structurally similar. Furthermore, it is demonstrated
that the 13C chemical shift difference deduced from the doublet splittings
can serve as a direct measure of the structural difference between the two
conformations, which could possibly correlate with the anti-tumor activity
of Taxol. |
| CLICK HERE to display the source webpage from "SpectroscopyNow.com" for the material below |
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Hu�ngq� is a plant root used in one of the most common tonics of Chinese herbal medicine with purported activity in cancer, diabetes, inflammation, and nephritis. As such, there is a lot of interest in the active ingredients of this species as it might lead to novel pharmaceuticals against a range of illnesses. Now, researchers in China have used proton NMR to identify active components, and report their results in the journal Magnetic Resonance in Chemistry. Xingang Du, Yanjing Bai, Hong Liang, Zhiying Wang, Yuying Zhao, and Qingying Zhang of the School of Pharmaceutical Sciences, at Peking University Health Science Center, in Beijing and Luqi Huang of the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, also in Beijing, have focused on the chemistry of extracts of Astragalus membranaceus var. mongholicus. The dry roots of this leguminous plant, more usually known as Radix Astragali, or hu�ngq� (yellow leader) in traditional Chinese medicine (TCM) is one of the most important tonics used to reinforce "Qi" (the principle of vital energy in TCM). Practitioners claim that this strengthens superficial resistance to disease, promotes the discharge of pus and the growth of new tissue. In clinical tests it has demonstrated physiological activity in liver protection, as an antioxidant, an antiviral compound, and in lowering blood pressure and stimulating the immune system. The researchers used one- and two-dimensional NMR, including 1H, 13C, COSY, HSQC, HMBC, and NOESY sequencesto establish structures of extracts of hu�ngq�. They isolated four 3'-hydroxy-4'-methoxy-isoflavonoids from the dried roots. Namely, calycosin-7-O-beta-D-glucopyranoside, calycosin, pratensein-7-O-beta-D-glucopyranoside, and pratensein. This latter compound was previously unknown and represents a potential new lead for the development of novel pharmaceuticals from this traditional remedy. Interestingly, the team found that during structural elucidation of the compounds, solvent obscured the proton signal patterns somewhat producing mis-assignments. The team therefore used a range of deuterated solvents to side-step this issue and were able to correctly assign the novel compound with confidence as well as correct the previously reported literature structures for the others. Related links: |
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Advances in Chemistry and Environmental Impact PROGRAMME November 2, 2006 Registration: 8.30 - 9.00 hrs. Inauguration: 9.00 - 9.20 hrs. November 2, 2006 Registration: 8.30 - 9.00 hrs. Inauguration: 9.00 - 9.20 hrs. Address: G. N. Pandey (BRNS) 9.20 - 9.40 hrs. Keynote address: S. K. Kulshreshtha (BARC) 9.40 - 10.20 hrs. Chairperson: P. Tandon Tea Break: 10.20 - 10.45 hrs. Session - I 10.45 - 11.15 hrs. S. B. Roy (UED, BARC) 11.15 - 11.35 hrs. V. S. Ghole (Pune) 11.35 - 12.00 hrs. S. K. Jha (BARC) 12.00 - 12.25 hrs. Dalia Nayak (SINP) 12.25 - 12.45 hrs. M N V Prasad (Hyderabad) Chairperson: S. K. Kulshrestha Lunch Break: 12.45 - 13.30 hrs. Session - II 13.30 - 14.00 hrs. S.P. Bhattacharyya (IACS) 14.00 - 14.30 hrs. S. P. Moulik (Kolkata) 14.30 - 14.50 hrs. R. C. Deka (Tezpur) 14.50 - 15.10 hrs. B. Pal (CCMB) Chairperson: M. K. Mahanti Tea Break: 15.10 - 15.30 hrs. 15.30 - 16.00 hrs. N. Satyamurthy (IIT-K) 16.00 - 16.20 hrs. S. Adhikari (IIT-G) Chairperson: S. P. Bhattacharyya Session - III Poster Presentation: 16.30 - 18.00 hrs. Cultural Programme: 18.00 - 19.30 hrs. Dinner : 19.30 - 21.00 hrs. November 3, 2006 Session - IV 9.00 - 9.30 hrs. H. Junjappa 9.30 - 9.50 hrs. A. T. Khan (IIT-G) 9.50 - 10.10 hrs. U. Bora Sinha (Nagaland) 10.10 - 10.30 hrs. R S Rao (Andhra Uni) Chairperson: S. P. Moulik Tea Break : 10.30 - 11.00 hrs. 11.00 - 11.30 hrs. H. Ila (Kanpur) 11.30 - 11.50 hrs. S. B. Waghmode (Pune) 11.50 - 12.10 hrs. N. S. Islam (Tezpur) Chairperson: H. Junjappa Lunch Break: 12.30 - 13.15 hrs. Session - V 13.15 - 13.45 hrs. M K Chaudhuri (IIIT-G) 13.45 - 14.10 hrs. K Natarajan (Bharatihar) 14.10 - 14.30 hrs. R K Lonibala (Manipur) 14.30 - 14.50 hrs. M Ray (IIT-G) Chairperson: P. Mathur Tea Break: 14.50 - 15.10 hrs. 15.10 - 15.40 hrs. P Mathur (IIT-B) 15.40 - 16.00 hrs. D K Chand (IIT-M) Chairperson: M. K. Chaudhuri Concluding Session 16.00 - 16.30 |
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Enumerating Environmental Applications in Chemical Research With NMR Spectroscopy Advances in Chemistry requires the reinforcements from the Fund of methodologies and know-how available in NMR Spectroscopic techniques and the resource databases setup from the outputs at the Installations of NMR facilities with access from and far and near. The scope is vast for the reach of NMR spectroscopy making inroads into several disciplines and at present it is probably beyond the grasp of many as to what the frontier achievements signaling the potential applications of the NMR technique. It is intended to enumerate in an elementary way the applications of NMR spectroscopy on environment related subject matters so that this can stimulate the researchers with a query as to whether there are any simpler methods available for Chemists other than the NMR methods for realizing similar results. Salient topics to be covered include: Investigation of a patient withMC Ardle�s Syndrome(Ref.1) References: A link to the webpage of the
Manufacturers of NMR spectrometers-"BRUKER" of Switzerland |
SHEET # 4 to 7 Describe the utility of 31P NMR spectroscopy in the in vivo NMR studies for monitoring the intracellular conditions human body. The chemical criteria are underlined in the text and the NMR advantages are highlighted. Some pertinent questions addressed are whether the ailments can be characterized as due hereditary consequences or as due to environmentally causes. SHEET # 8-10 Contain the application of Solid state NMR techniques to characterize coals and coal products. The model for structure of coal and based on this the determination of the ratio of aromatic/ aliphatic carbon contents by solid state NMR ids reported. This ratio is a criterion that is useful in determining the coal product from mines. SHEET #11-12 7Li is toxic element. The nucleus of this lithium isotope is NMR active. This toxic element is used as a tracer element in monitoring certain disease conditions which is explained in these sheets. SHEET # 13-14 The NMR technique has the facility to monitor the quality of day to day food material like the Milk. These sheets indicate the study for trying to find differences in bullfallo and cow milk with the 31P NMR spectroscopy. SHEET # 15-16 From the web pages of the NMR Manufacturer �BRUKER
BIOSPIN�. Their product named �minispec� model is a bench top NMR system
with which a variety of applications of day to day materials and house
hold items are envisaged in their application notes. An example of how fat
contents are analysed are
indicted. |
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The materials displayed in this poster are not the results of the Research Work of the presenter. The contents are the outcome of literature awareness on the Chemical problems which pertain to Environment related issues. ENVIRONMENTAL aspects cover, besides the much publicized and most frequently encountered pollution-prevention measures, the concerns of health problems of victims of environmental hazards, safeguarding the quality of food produced and sold in the markets, and the quality control of manufactured food stuffs, fuel conservation, quality improvement and efficient consumption. In all these cases it is the chemical constituents and the composition of materials which are the subject of study. While relating to health problems; 1) toxicity and pollution by toxic trace elements have to be enlisted 2) attention must be given to tracking the toxic elements and 3) methods have to be found to treat the patients suffering from the ailments due to the toxicity. While all these can be formulated as the problems to be characterized as Chemical nature, finding solutions to these essentially follow the pattern of chemical research. Spectroscopy is an inevitable tool, and on the basis of the familiarity which the Techniques of NMR Spectroscopy, and the awareness about the meager extent to which researchers in Chemistry get updated with the advances in NMR techniques while trying to cope up with the Chemical research leading to solution to environmental aspects, this presentation enumerates some of the results which appeal as evoking simple chemical principles, but require the advanced NMR techniques for the simple solutions. While application of all the advanced NMR techniques finally yields conventionally appealing NMR information to realize solutions. But without the advanced techniques such simple information cannot be the result. In this enumeration, it is not the interest to detail the NMR techniques and their developments which make all these possible: but, to point out the simple NMR information which can give elegant solutions to environment related aspects with the knowledge of elementary chemistry. Even all the chemical details would not be addressed to in this poster but would be given enough elaboration so that a chemist would start asking for more details on the Chemistry part and eventually be enthused to know the relative importance of NMR technique to arrive at the detailed chemical information required.
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